Study 1: VERISOL® collagen peptides helped reduce the appearance of crow's-feet wrinkles

• Results: Crow's-feet wrinkle volume ↓ ≈20% versus placebo
• Design: Double-blind RCT, 2.5g/day, n=114 women, 45–65 years, 8 weeks
• Study: Proksch et al., Skin Pharmacol Physiol 2014;27(3):113-9 (PMID 24401291)

Study 2: VERISOL® collagen peptides improved skin elasticity, with the benefit still present four weeks after stopping

• Results: Both the 2.5g and 5g dose groups showed significantly higher elasticity vs. placebo at 4 and 8 weeks (mean increase ≈7%). In the elderly-women subgroup, elasticity was still statistically significantly higher than placebo at the 4-week follow-up after stopping supplementation — the paper reports this as retaining about 98% of the treatment effect after four weeks off the product.
• Design: Double-blind RCT, 2.5g or 5g/day, n=69 women, 35–55 years, 8-week treatment + 4-week follow-up
• Study: Proksch et al., Skin Pharmacol Physiol 2014;27(1):47-55 (PMID 23949208)

Study 3: Astaxanthin helped improve skin texture and reduce fine lines

• Results: Significantly better skin texture score vs. placebo at both 4 and 8 weeks; water content, TEWL, viscoelasticity, and erythema also improved
• Design: Double-blind RCT, 3mg/day astaxanthin drink, n=20 Japanese women aged 30–50, 8 weeks
• Study: Tsukahara et al., Jpn J Complement Altern Med 2016;13(2):57-62

Study 4: Beta-carotene at a low dose helped improve facial wrinkles and stimulate collagen production

• Results: In the 30mg/day (low-dose) group only — facial wrinkles and elasticity improved significantly, type I procollagen mRNA rose to 4.4× baseline, and UV-induced DNA damage markers decreased. The 90mg/day (high-dose) group did not show the same benefit, and one UV-damage marker trended worse at the high dose.
• Design: RCT, 30mg/day vs. 90mg/day beta-carotene vs. baseline control, n=30 women over 50, 90 days
• Study: Cho S, Lee DH, Won CH, et al., Dermatology 2010;221(2):160-71

Study 1: Ceramosides™ (wheat-derived ceramides) improved skin hydration, reduced water loss, and improved elasticity, smoothness, and wrinkledness

• Results: hydration ↑, TEWL ↓, elasticity ↑, wrinkledness ↓, smoothness ↑, roughness ↓ at both 15 and 60 days, all significant vs. both baseline and placebo (p≤0.001).
• Design: Double-blind, placebo-controlled, 60 women with dry/photoaged skin, 30mg/day (powder) or 70mg/day (oil), 60 days
• Study: Bizot, Cestone, Michelotti & Nobile, Cosmetics 2017;4(4):37
  

Study 2: Ceramosides™ increased skin hydration and elasticity within 56 days

Study results: Hydration ↑ ≈19%; skin elasticity ↑ ≈18%

Design: Double-blind, placebo-controlled RCT, 30mg/day (powder) or 70mg/day (oil), n=72 women, 56 days

Study: Kern et al., J Cosmet Dermatol 2024;23(4):1320-1330

Study 3: Red Orange Complex® improved skin moisturization, radiance, and reduced water loss

• Results at 56 days vs. baseline (active arm): moisturization ↑12.3%, skin radiance ↑18.5%, individual typology angle (tone) ↑32.9%, TEWL ↓14.5%, wrinkle depth ↓6.9% — all significantly better than placebo.
• Design: Randomized, double-blind, controlled, 100mg/day, n=110 Asian and Caucasian adults, 56 days
• Study: Nobile et al., Nutrients 2022;14(11):2241

Study 4: Lutein + zeaxanthin supplementation improved overall skin tone

• Results: Overall skin tone significantly improved vs. placebo (P<0.0237); luminance and individual typology angle also significantly increased.
• Design: Double-blind RCT, 10mg lutein + 2mg zeaxanthin/day (exact match to ASN's dose), n=46 completers, 12 weeks
• Study: Juturu, Bowman & Deshpande, Clin Cosmet Investig Dermatol 2016;9:325-332 (PMID 27785083)

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Red Orange Complex® reduced UV-induced dark spot pigmentation

• Results: Skin age-spot pigmentation (melanin content in solar lentigines) decreased from 27% to 7% during supplementation under UV exposure; UV-induced erythema also significantly reduced
• Design: 100mg/day, n=20 (erythema arm) + n=25 (pigmentation arm), 15 days
• Study: Puglia et al., J Cosmet Dermatol 2014;13(2):151-7

Study 2: Red Orange Complex® decreased the intensity of melanin staining and improved skin tone

• Same study as Section 2 (Nobile et al., Nutrients 2022) — the 56-day trial also measured melanin staining and tone-evenness (ITA ↑32.9% vs. baseline).

Study 3: Lutein + zeaxanthin improved overall skin tone

• Results: Overall skin tone significantly improved vs. placebo (P<0.0237); luminance and individual typology angle also significantly increased.
• Design: Double-blind RCT, 10mg lutein + 2mg zeaxanthin/day, n=46 completers, 12 weeks
• Study: Juturu, Bowman & Deshpande, Clin Cosmet Investig Dermatol 2016;9:325-332

Study 4: Lycopene helped protect skin at the molecular level against UV-induced damage

• Results: A lycopene-rich tomato nutrient complex (5mg lycopene) completely blocked UVA1- and UVA/B-induced upregulation of three skin-damage marker genes (heme-oxygenase-1, ICAM-1, MMP-1) in skin biopsies, regardless of treatment order.
• Design: Placebo-controlled, double-blind, randomized crossover, n=65 healthy adults, two 12-week treatment phases
• Study: Grether-Beck et al., Br J Dermatol 2017;176(5):1231-1240

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Polypodium leucotomos helped support the skin's natural tolerance to UV

• Results: reduced UV-induced skin damage in a phototoxicity (PUVA) model
• Study: Middelkamp-Hup et al., J Am Acad Dermatol 2004;50(1):41-9, and/or J Am Acad Dermatol 2004;51(6):910-8

Study 2: Polypodium leucotomos helped reduce visible-light-induced pigment darkening in deeper skin tones

• Results: Spectroscopic measures showed a statistically significant decrease in persistent pigment darkening and delayed tanning after supplementation.
• Design: Open study, 480mg/day, n=22 adults, Fitzpatrick IV–VI, 28 days
• Study: Mohammad, Kohli et al., J Drugs Dermatol 2019;18(12):1198-1203

Study 3: Niacinamide helped maintain normal immune markers after UV stress

• Results: UV-induced immunosuppression reduced significantly vs. placebo at the 500mg/day dose (matches ASN's niacinamide dose exactly)
• Design: Crossover, 500mg/day cohort (n=31) and a separate 1,500mg/day cohort (n=30), 1 week
• Study: Yiasemides et al., Carcinogenesis 2009 (PMID 19028705)

Study 4: Red Orange Complex® improved the skin's antioxidant capacity and reduced UV-induced lipid damage

• Study results: Skin antioxidant capacity (FRAP) ↑ ≈22% at day 56 vs. baseline, significant vs. placebo; skin lipid peroxidation (MDA) ↓ ≈8% at day 56 vs. baseline, also significant vs. placebo, including after a UVA challenge to the skin
• Design: Same 56-day trial as above — randomized, double-blind, controlled, 100mg/day, n=110 Asian and Caucasian adults, measured on skin strippings
• Study: Nobile et al., Nutrients 2022;14(11):2241

Study 5: EGCG (green tea) reaches the skin after oral consumption

• Results: Multiple green tea catechins were detected in skin biopsies, blister fluid, and plasma after 3 months of green tea + vitamin C consumption, confirming EGCG and its metabolites are bioavailable in skin tissue.
• Design: Open oral intervention, n=11 adults, 3 months
• Study: Clarke et al., J Nutr Biochem 2016;27:203-10 (PMID 26454512)

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Niacinamide is a building block your body uses to make NAD⁺

• Results: A single 200mg dose of niacinamide raised blood nicotinamide (the precursor) roughly 30-fold within 30 minutes — a rapid, transient spike. NAD⁺ itself rose separately and more modestly, peaking at 12 hours with about a 21% increase, before metabolomic changes returned to baseline by 48 hours.
• Design: Open-label, single 200mg dose, n=6 healthy male volunteers
• Study: Ito, Sato, Hakamata et al., Translational Medicine of Aging 2020;4:45-54

Study 2: Astaxanthin reduced markers of oxidative stress

• Results: Plasma malondialdehyde (an oxidative-stress marker) decreased 11.2% at day 15 and 21.7% at day 29; corneocyte desquamation and microbial presence on skin also decreased significantly
• Design: 4mg/day (exact match to ASN's dose), n=31 adults over 40, 4 weeks
• Study: Chalyk et al., Nutr Res 2017;48:40-48

Study 3: Zinc and selenium support the body's antioxidant defense system

• Zinc acts as an antioxidant and anti-inflammatory agent by inhibiting oxidative damage to DNA, RNA, and proteins (Prasad, J Trace Elem Med Biol 2014; Prasad & Bao, Antioxidants 2019)
• Selenium supports antioxidant defense and helps protect keratinocyte stem cells against senescence (Jobeili et al., Aging 2017)

Study 4: Zinc picolinate absorbs better than other common zinc forms

Results: Hair, urine, and erythrocyte zinc levels rose significantly with zinc picolinate; no significant change occurred with zinc citrate, zinc gluconate, or placebo

Design: Four-way crossover, equimolar doses (50mg elemental zinc), n=15 adults

Study: Barrie et al., Agents Actions 1987;21(1-2):223-228

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: A wheat-derived ceramide complex reduced hair shedding and improved hair growth

• Results: Decreased telogen (shedding-phase) hair proportion and increased anagen (growth-phase) proportion, significant by day 56; reduced hair shedding on pull test; improved growth and breakage resistance by day 84; effects held in a postmenopausal subgroup
• Design: Double-blind, placebo-controlled, 30mg/day, n=66 women with >15% telogen hair, 84 days
• Study: Dudonné, Kern & Garcia, Int J Cosmet Sci 2024;46(2):284-296 (PMID 37935579)

Study 2: Ceramosides™ reduced hair shedding and increased hair growth in women with acute hair loss

• Results: telogen (shedding-phase) hair density decreased 24–27% (active arms) vs. 11% (placebo) by day 84; anagen (growth-phase) density increased ~10–11% vs. 5% placebo; anagen:telogen ratio improved 53–62% vs. 22% placebo; hair-pull test improved 41–44% vs. 29% placebo; hair growth rate improved 11–17% vs. placebo.
• Design: Double-blind, placebo-controlled, n=99 women aged 18–65 with acute telogen effluvium, 30mg/day (powder) or 70mg/day (oil), 56–84 days
• Study: Nobile V, Dudonné S, Kern C, Cestone E, Garcia C, "Recovery Effects of Oral Supplementation with Polar Lipid-Rich Wheat Extracts on Acute Telogen Effluvium: A Randomized Double-Blind Placebo-Controlled Study." Clin Cosmet Investig Dermatol 2025;18:1239-1251 (PMID 40416946)

Study 3: VERISOL® collagen peptides increased hair thickness and stimulated hair follicle cell activity

• Results: Hair thickness increased significantly by 1.93µm in the treatment group (vs. a non-significant decrease in placebo); a separate ex-vivo assay showed hair follicle cell proliferation increased 31%
• Design: Placebo-controlled, 2.5g/day, n=44 women aged 39–75, 16 weeks
• Study: Oesser, Nutrafoods 2020;1:134-138 (DOI 10.17470/NF-020-0019)

Study 4: VERISOL® collagen peptides improved nail growth and reduced symptoms of brittle nails

• Study results: Nail brittleness ↓ 42%; nail growth rate ↑ 12%
• Design: 2.5g/day, n=25 women, 24 weeks
• Study: Hexsel et al., J Cosmet Dermatol 2017;16(4):520-526

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Astaxanthin improved visual acuity and eye-focusing speed after screen-related visual tasks

• Results: At the 4mg/day dose and above, uncorrected far visual acuity significantly improved and accommodation time (how fast the eye refocuses) significantly shortened after 28 days; no change in refraction, flicker fusion, or pupillary reflex
• Design: 4 dose groups (0/2/4/12mg/day), n=49 adults over 40, 28 days. Open dose-comparison study, not an RCT.
• Study: Nakamura, Isobe & Otaka, Japanese Journal of Clinical Ophthalmology 2004;58(6):1051-1054
  

Study 2: Lutein + zeaxanthin support visual comfort during heavy screen use

• Lopresti & Smith, Frontiers in Nutrition 2025;12:1522302 — 10mg lutein + 2mg zeaxanthin/day (exact match to ASN), n=70 adults using screens >6 hrs/day, 180 days. Objective tear-film and photostress-recovery measures improved significantly vs. placebo. 
• Stringham, O'Brien & Stringham, Eye and Vision 2016;3:30 — macular carotenoids (10mg lutein + 1mg zeaxanthin + 1mg meso-zeaxanthin/day, or double that), n=59, 12 months. Significantly faster photostress recovery and better glare tolerance at 6 and 12 months.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.