Study 1: Daily VERISOL® collagen peptides helped reduce the appearance of crow’s-feet wrinkles

• Study Results: Crow’s-feet wrinkle volume ↓ ≈20% versus placebo
• Design: Double-blind RCT (Randomized Controlled Trial), 2.5g/day, n=114 women, 45–65 years, 8 weeks
• Study: Proksch et al., Skin Pharmacol Physiol 2014

Study 2: Four weeks of VERISOL® helped improve skin elasticity, and the benefit persisted after supplementation stopped

• Study Results: Skin elasticity ↑ 10–15%; benefit persisted 4 weeks post-stop
• Design: Double-blind RCT, 2.5g/day, n=69 women, 35–55 years, 4 weeks
• Study: Proksch et al., Skin Pharmacol Physiol 2014

Study 3: VERISOL® increased dermal-collagen density and reduced wrinkle depth in a split-face trial

• Study Results: Dermal collagen density ↑; wrinkle depth ↓ ≈24%
• Design: Split-face study, 2.5g/day, n=60 women, 12 weeks
• Study: El‑Domyati et al., J Cosmet Dermatol 2023
  

Study 4: Natural astaxanthin helped reduce the appearance of wrinkle depth and supported firmer-looking skin

• Study Results: Wrinkle depth ↓ 13%; firmness appearance ↑ 9%
• Design: Placebo-controlled, 4mg/day, n=65 adults, 12 weeks
• Study: Tominaga et al., Nutrients 2017
  

Study 5: β-Carotene supplementation helped improve facial-wrinkle appearance and elasticity in mature women

• Study Results: Gross wrinkle score ↓; skin elasticity ↑ (both significant vs baseline)
• Design: Randomized controlled trial, 30mg/day, n=30 women > 50 years, 90 days
• Study: Kim & Kim, Nutr Res 2012

·Note: The study used 30mg/day, while ASN provides 6mg/day (see FAQ)

Study 6: Low-molecular collagen peptides helped boost hydration and reduce the appearance of wrinkle depth

• Study Results: Skin hydration ↑ 26%; wrinkle depth ↓ 25%
• Design: Double-blind RCT, 2.5g/day, n=90 adults, 8 weeks
• Study: Marques et al., Dermatol Ther 2019
  

Study 7: Collagen-peptide ingestion stimulated dermal-matrix protein expression ex-vivo

• Study Results (ex-vivo): Pro-collagen I mRNA ↑ 65%; elastin ↑ 18%
• Design: Ex-vivo / PK (pharmacokinetic) crossover study, 2.5g dose; human PK subset n=10
• Study: Oesser et al., Nutr Res 2020
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Ceramosides™ helped increase skin moisture and reduce water loss

• Study results: Hydration ↑ ≈16%; TEWL (transepidermal water loss) ↓ ≈22%
• Design: Double-blind RCT, 30mg day, n=40 adults, 15 days
• Study: Boisnic et al., Clin Cosmet Investig Dermatol 2013
  

Study 2: Sixty days of Ceramosides™ further improved elasticity

• Study results: Skin elasticity ↑ about 19%
• Design: Double-blind RCT, 30mg day, n=40 adults, 60 days
• Study: Roussel et al., J Clin Exp Dermatol Res 2015
  

Study 3: A wheat-lipid ceramide complex increased moisture and smoothed the appearance of micro-wrinkles

• Study results: Moisture ↑ 41%; appearance of micro-wrinkles ↓ 16%
• Design: Pilot, 20mg day, n=20 women, 60 days
• Study: Leroy et al., Nutrients 2014
  

Study 4: Twelve weeks of niacinamide refined the appearance of tone and strengthened barrier lipids

• Study results: Appearance of uneven pigmentation ↓; barrier ceramides ↑; skin-tone evenness index improved 8-9% vs placebo (facial imaging software)
• Design: Double-blind RCT, 500mg day, n=50 adults, 12 weeks
• Study: Tran et al., Photodermatol Photoimmunol Photomed 2021
  

Study 5: Red-orange polyphenols eased visible redness and improved brightness

• Study results: Redness ↓ 26%; TEWL ↓; overall brightness ↑ 5-6%
• Design: Randomized, 100mg day, n=100 adults, 30 days
• Study: Speranza et al., J Cosmet Dermatol 2022
  

Study 6: Vitamin C plus ceramides supported moisture retention and key barrier proteins

• Study results: Hydration ↑ 25%; filaggrin protein expression (barrier protein) ↑ 21%
• Design: RCT, 500mg vitamin C + ceramides, n=40 adults, 12 weeks
• Study: Kawada et al., J Dermatol Sci 2014
  

Study 7: Lutein + zeaxanthin supported higher hydration and UV-tolerance thresholds

• Study results: Hydration ↑ ≈60%; MED (minimum erythema dose) ↑ ≈14%
• Design: Double-blind RCT, 10mg L + 2mg Z per day, n=50 adults, 12 weeks
• Study: Palombo et al., Skin Pharmacol Physiol 2007
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Red-orange polyphenols helped reduce visible redness and brighten overall tone

• Study results: Redness ↓ 26%; brightness ↑ ≈5-6%; TEWL ↓ 12%
• Design: Randomized, 100mg day, n=100 adults, 30 days
• Study: Speranza et al., J Cosmet Dermatol 2022
  

Study 2: Oral niacinamide helped smooth uneven pigmentation and strengthen barrier lipids

• Study results: Appearance of uneven pigmentation ↓ ≈10%; barrier ceramides ↑ vs placebo
• Design: Double-blind RCT, 500mg day, n=50 adults, 12 weeks
• Study: Tran et al., Photodermatol Photoimmunol Photomed 2021
  

Study 3: β-Carotene supplementation lightened the appearance of age spots

• Study results: Melanin index ↓ 7% at week 12 (significant vs baseline)
• Design: Randomized controlled trial, 30mg day, n=30 women > 50y, 90 days
• Study: Kim & Kim, Nutr Res 2014

Study 4: Tomato-derived lycopene helped support the skin’s response to photodamage 

• Study results: UV-induced redness ↓ 40% 
• Design: Controlled-feeding, 16mg lycopene as tomato paste, n=20 adults, 10 weeks 
• Study: Rizwan et al., Br J Dermatol 2011 
• Note: The study used 16mg/day, while ASN provides 6mg/day (see FAQ)
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Polypodium leucotomos helped support the skin’s natural tolerance to UV

• Study Results: In the study, MED was ≈180% higher for about two hours after a single 480mg dose
• Design: Crossover, single 480mg, n=10 adults, acute
• Study: Middelkamp-Hup et al., J Invest Dermatol 2004
  

Study 2: Four weeks of Polypodium leucotomos helped reduce UV-related redness

• Study Results: In the study, UV redness was ≈ ↓ 35% vs placebo; lipid peroxidation marker (MDA) ↓ 32% vs baseline
• Design: Double-blind RCT, 240mg twice daily, n=20 adults, 4 weeks
• Study: Philips et al., J Photochem Photobiol B 2009
  

Study 3: Natural astaxanthin helped improve the skin’s sun-tolerance index

• Study Results: In the study, tolerance to simulated sunlight was ≈ 18% higher vs placebo
• Design: Placebo-controlled, 4mg/day, n=65 adults, 12 weeks
• Study: Tominaga et al., Nutrients 2017
  

Study 4: Green tea catechins helped modulate the skin’s response to UV exposure

• Study Results: UV-induced redness was ≈ 20% lower vs placebo in the study; endogenous skin catechin levels ↑ 17%
• Design: Double-blind RCT, 140mg/day, n=40 adults, 12 weeks
• Study: Rhodes et al., Br J Nutr 2013
  
  

Study 5: Lutein + zeaxanthin supported higher UV tolerance and better hydration

• Study Results: Hydration ↑ ≈60%; MED ↑ ≈14% in the study
• Design: Double-blind RCT, 10mg L + 2mg Z/day, n=50 adults, 12 weeks
• Study: Palombo et al., Skin Pharmacol Physiol 2007
  

Study 6: Niacinamide helped maintain normal immune markers after UV stress

• Study Results: UV-induced immunosuppression ↓ ≈35% vs placebo
• Design: Crossover, 500mg/day, n=38 adults, 5 days
• Study: Yiasemides et al., Carcinogenesis 2009
  

Study 7: Daily Polypodium leucotomos lessened visible-light-induced darkening in deeper skin tones

• Study Results: Persistent pigment darkening score decreased (statistically significant vs baseline); visible-light pigmentation area ↓ 11% at day 28 (image analysis)
• Design: Open study, 480mg/day, n=22 adults (Fitzpatrick IV-VI), 28 days
• Study: Kohli et al., J Drugs Dermatol 2019
  

Study 8: Additional Evidence: Maqui-berry anthocyanins helped maintain antioxidant balance under UV stress

• Study Results: Plasma ORAC (Oxygen Radical Absorbance Capacity) ↑ 17%; ↓ UV-induced ROS (reactive-oxygen species)
• Design: Open pilot, 100mg/day, n=24 adults, 8 weeks
• Study: Morales-Guerrero et al., J Nutr Biochem 2023
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Twice-daily niacinamide supported normal cell-maintenance pathways in UV-exposed skin

• Study Results: In the study, new non-melanoma lesions ↓ 23%; actinic-keratosis counts ↓ 11% at month 4, and ↓ 20% at month 12 vs placebo
• Design: Phase-III double-blind RCT, 500mg BID, n=386 adults, 12 months
• Study: Chen et al., N Engl J Med 2015
  

Study 2: Daily vitamin D₃ helped preserve key epidermal-differentiation markers during low-sun winter months

• Study Results: Differentiation markers remained stable in the vitamin D₃ group but declined in placebo (significant between-group difference); TEWL ↓ 14% vs baseline
• Design: Double-blind RCT, 1,000 IU/day, n=60 adults, 12 weeks
• Study: Kim et al., Skin Pharmacol Physiol 2016
  

Study 3: Maqui-berry anthocyanins helped maintain antioxidant balance under UV stress

• Study Results: Plasma ORAC (Oxygen Radical Absorbance Capacity) ↑ 17%; UV-induced reactive-oxygen species ↓; erythrocyte superoxide-dismutase activity ↑ 12%
• Design: Open pilot, 100mg/day, n=24 adults, 8 weeks
• Study: Morales-Guerrero et al., J Nutr Biochem 2023
  

Study 4: Grapeseed OPCs (oligomeric proanthocyanidins) reduced markers of UV-related oxidative stress

• Study Results: UV oxidative markers ↓ ≈ 18%; protein-carbonyl formation ↓ 15% vs control
• Design: Crossover, 95mg OPCs/day, n=19 adults, 4 weeks
• Study: McAnulty et al., J Med Food 2009
  

Study 5: Vitamin C plus ceramides supported higher moisture and key barrier proteins

• Study Results: Hydration ↑ 25%; barrier protein filaggrin ↑; TEWL ↓14 %; epidermal involucrin ↑ 18% (involucrin is a marker of a well-differentiated skin barrier)
• Design: RCT, 500mg vitamin C + ceramides, n=40 adults, 12 weeks
• Study: Kawada et al., J Dermatol Sci 2014
  

Study 6: Zinc picolinate delivered greater zinc uptake than other common salts

• Study Results: Plasma zinc AUC ↑ 24% vs zinc oxide; whole-body zinc retention at 14 days ↑ 31% vs citrate/gluconate
• Design: Three-way crossover absorption study, equimolar doses, n=15 adults
• Study: Barrie et al., Agents Actions 1987
  

Study 7: MCT oil roughly doubled bloodstream levels of astaxanthin

• Study Results: Plasma astaxanthin ≈ 2× higher vs olive-oil control: Cmax ≈ 2.1× and AUC ≈ 2× higher vs olive-oil control; Tmax shortened from 7h to 4h
• Design: PK crossover, 4mg astaxanthin + 2g MCT, n=12 adults
• Study: Sugimoto et al., Foods 2020
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: VERISOL® collagen peptides helped strengthen brittle nails and boost nail growth

• Study Results: Nail brittleness ↓ 42%; nail-growth rate ↑ 12%
• Design: Open-label, 2.5g/day, n=25 women, 6 months
• Study: Hexsel et al., J Cosmet Dermatol 2017
  

Study 2: A confirmatory RCT with the same wheat-lipid ceramide complex increased growth-phase hairs

• Study Results: Anagen (growth-phase) hairs ↑; hair-pull counts ↓; hair diameter ↑ 3µm (+6 %)
• Design: Double-blind RCT, 30mg/day, n=99 women, 90 days
• Study: Leroy et al., Clin Cosmet Investig Dermatol 2023
  

Study 3: Low-molecular collagen peptides helped thicken hair shafts while supporting skin benefits

• Study Results: Hair-shaft thickness ↑ (significant vs baseline)
• Design: Double-blind RCT, 2.5g/day, n=90 adults, 8 weeks
• Study: Marques et al., Dermatol Ther 2019
  

Study 4: A pilot trial with Ceramosides™ reduced hair shedding and improved break-resistance

• Study Results: Telogen (shedding) hairs ↓ 14% by day 56; break-resistance ↑ 13%
• Design: Pilot, 30mg/day, n=66 women, 84 days
• Study: Leroy et al., J Cosmet Dermatol 2021
  

Study 5: Bamboo-derived silica helped support stronger hair shafts and less-brittle nails

• Study Results: Hair tensile strength ↑ 13%; nail brittleness ↓ 16%
• Design: Open-label, 10mg elemental silica/day, n=50 adults, 9 months
• Study: Barel et al., Arch Dermatol Res 2005
  

Study 6: Green-tea catechins helped improve hair-shaft elasticity and surface gloss

• Study Results: Hair-shaft elasticity ↑ 8%; gloss score ↑ 12%
• Design: Pilot, 140mg catechins/day, n=34 adults, 4 months
• Study: Kwon et al., Phytomedicine 2018
  

Study 7: Collagen-peptide ingestion stimulated hair-follicle cell activity ex-vivo

• Study Results: Follicle-cell proliferation ↑ 31% in ex-vivo tissue after a 2.5g dose
• Design: Ex-vivo/PK (pharmacokinetics) crossover, single 2.5g dose; human PK subset n=10
• Study: Oesser et al., Nutr Res 2020
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: VERISOL® collagen peptides helped improve the appearance of thigh- and buttock-cellulite

• Study Results: Cellulite-appearance score ↓10% at 3 months and ↓15% at 6 months vs placebo; dermis waviness ↓ 8% on high-resolution ultrasound at 6 months
• Design: Double-blind RCT, 2.5g/day, n=105 women, 6 months
• Study: Schunck et al., J Med Food 2015
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.

Study 1: Natural astaxanthin helped ease screen-related eye fatigue and improve focusing speed

• Study Results: Accommodation time after VDT task ↓ 1.7 frames; subjective fatigue ↓ 27%
• Design: Double-blind RCT, 4mg/day, n ≈ 25 participants (49 eyes), 4 weeks
• Study: Nitta et al., J Tradit Complement Med 2005
  

Study 2: Higher-dose lutein + zeaxanthin helped enhance contrast sensitivity and lessen visual fatigue symptoms

• Study Results: Contrast sensitivity ↑ 0.14 log units; visual fatigue ↓ 23%
• Design: RCT, 24mg L + Z per day, n=59 adults, 6–12 months
• Study: Renzi-Hammond et al., Nutrients 2017
  

Study 3: Lutein + zeaxanthin helped improve glare recovery and increase macular-pigment optical density (MPOD)

• Study Results: Glare recovery time improved by 5 sec; MPOD ↑ 0.07 optical density units
• Design: Double-blind RCT, 12mg L + Z per day, n=36 adults, 12 weeks
• Study: Stringham et al., J Food Sci 2011
  

Study 4: Lutein + zeaxanthin helped support visual comfort and cognitive performance while raising brain-derived neurotrophic factor (BDNF) and macular pigment (MPOD)

Study Results: Eye strain & visual-fatigue scores ↓; measures of cognitive-performance ↑ (focus, episodic memory & learning, visuospatial working memory); processing speed, attention, and visuospatial processing ↑; serum BDNF ↑; MPOD ↑

• Design: RCT, 12mg L + Z per day, n=80 adults, 6 months
• Study: Stringham et al., Nutrients 2019
  

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease. Results are from studies on individual ingredients; outcomes from the finished product may vary.